http://www.nytimes.com/2013/07/14/opinion/sunday/do-clinical-trials-work.html?src=me&ref=general
The above is an excellent summary of just how awful the situation is. It's very confusing and difficult to figure how to fix drug development.
It's just an intuitive judgement on my part but I think this continuing failure may push science into exciting new areas that are not 'materialistic' in nature.
metatron