Jesus meant it literally. His disciples walked away from their wives, children, businesses and everything they owned in order to follow him.
Following Jesus did not mean reading the bible and singing praises. It meant physically FOLLOWING him around Galilee and Judea.
Based on the false promise that the end was coming within that generation it made sense in that context.
Now I means whatever you want it to mean. The bible is like a magic carpet that will take you anywhere you desire and allow you to believe you are right. No wonder early Christianity was so small and the modern version is so popular.