FYI,
“We are only now starting to realize what happens to blood when it is drawn out of a human body and sent to the blood bank for storage. Blood undergoes changes profoundly, even in the first 24 hours. The major effect is loss of nitric oxide, which is really fundamental to the process of oxygen exchange.” - Dr. Sunil Rao, Duke assistant professor of medicine, Durham VA Medical Center.
Transfused blood, void of nitric oxide, sucks up nitric oxide from the tissues of the patient. This causes blood vessel constriction, reduces blood flow, which then may cause heart attack or stroke. Other problems with older blood, affect the immune system of patients. Patients receiving transfusion during surgery, often spend much longer in hospital recovering compared to those who manage to avoid transfusion.
"Nitric Oxide does everything, everywhere. You cannot name a major cellular response or physiological effect in which Nitric Oxide is not implicated today. It's involved in complex behavioural changes in the brain, airway relaxation, beating of the heart, dilation of blood vessels, regulation of intestinal movement, function of blood cells, the immune system, even how fingers and arms move." - Dr. Jonathan S. Stamler, Professor of medicine at Duke University Medical Center
Dr Stamler also feels that blood transfusion should be a last resort. "If I am bleeding very, very badly and my blood counts are very, very low, I would want a transfusion," Stamler says. "But I would also want a thoughtful physician by my side having to make that decision in a thoughtful way."
Video of Stamler talking about missing Nitric Oxide in stored blood.
http://www.youtube.com/watch?v=WwjNOu4Asiw
Note:
That video was dated 2007, from what I know, nothing so far as been done to stored blood to infuse nitric oxide - the problem remains (22/2/2010). I know there is ongoing research and increasing pressure on the FDA to change its policy on the length of time blood is allowed to be stored. The longer it's stored (>14 days) the more useless & dangerous it becomes to patients. Current policy is 42days.
Also see article
http://www.sciencentral.com/articles/view.php3?language=&type=&article_id=218393004
http://www.noblood.org
Thanks,
Mike.