Yesss, a friend of mine shoots Nikon and I've played with it a bit. I love the fact that you don't have to drill down through menus so much. The Canon Rebels were pretty limited with control/function accessibility. The 5DmkII is incredible in almost every way but still doesn't have as many hardware controls as the typical Nikon DSLR. But I LOVE having the freedom to shoot at ISO6400+ with acceptable noise that I can clean up later. (It's capable of reaching an equivalent of 25,600 but I'll never use it.)
Nikon (vs Canon) has a good handle on AF and minimal noise, don't they?