It's already been said but that might be about the time he started to realize that his patrons aren't coming back. Chances are when he lost supporters, he assumed he'd find new people ready to throw their weight behind him because he's just that important, and they would see it his way when it comes to where he parks his dick and how he's the victim in everything.
But, not only has he been deserted by anyone that matters but he can't even find a YouTuber with more than a few thousand subscribers to give him the time of day.
He might also be realizing that his remaining supporters can do nothing for him... people like Karen Morgan and Dave Gracey, no disrespect for what they've been through but they don't bring anything to Lloyd's table. O'Donnell gave him news and stories, filmmakers gave him a chance to be on camera, reporters gave him room in their stories, etc.
I would bet he's actually resentful that they can do nothing for him but talk on twitter, and twitter doesn't put money in your pocket. I wouldn't doubt if one day he lashes out at them as well.