When testing has been carried out on telepathy and ESP, sometimes it works and sometimes it doesn't, the results are very random and therefore difficult to quantify empirically. It reminds me of, I think it was Dawkins, talking about the evolution of the eye. He said that creationists mock and say what would be the use of having part of an eye. Dawkins explained being able to detect light and movement would be a huge advantage to a species starting to develop basic eyes.
I think it may be the same with telepathy and ESP, it's very random and hard to prove under laboratory conditions because it's only partially formed, still evolving. People who listen to their hunches and live more intuitively have an advantage over those that don't. Doesn't mean you don't use your rational brain but it just means you don't ignore the more unexplainable parts of our mind, hunches, intuition, feelings.
I don't think drugs are going to help your brain though EoM. Brain chemistry is extremely sensitive, I wouldn't advise playing around with it. Experimenting by listening to your intuition is much safer.