Endosymbiosis doesn't nullify the fact that all evolutionary change occurs by selective pressures changing the frequency of alleles (gene variants). More times than not, these genes aren't mobile, so aren't shared across organisms.
However, Margulis' insight has expanded our understanding the way life forms can diversify. Its a beautiful addition to the initial simple view of evolution. Lateral gene transfer has probably contributed greatly to the earliest stages of evolution of life on earth.
How our own evolution has been altered by incorporating genes from other organisms is interesting to explore. There's some papers I read once discussing how the mammalian placenta owed some of its development to viral genes.
I'd have to agree with one thing FD said:endosymbiosis doesn't seem to have been the key driving mechanism for our speciation from other earlier hominds.
That said, Auld Soul may find it interesting that there was a paper I came across once on how parasites may have contributed to furthering bipedalism in Austrolopithecus. That's not endosymbiosis or symbiosis, really, but more generally how the interactions of two organisms can affect the evolution of both. Alot of us have been taught about the "arms race" of predator and prey but not too much is made of other types of ecological relationships and its impact of evolution.
While endosymbiosis isn't likely to be the most predominant form of evolution thats occuring at any one time (or maybe not even the most prevalent overall), I'd have to say that it has the most potential for radical change - so its a very important factor.