http://maps.org/research/index.html
Johns Hopkins Study of Psilocybin in Cancer Patients
Investigators: Roland Griffiths PhD, William Richards PhD, Matthew Johnson, Ph.D., Una McCann, M.D.
Sponsor: Heffter Research Institute, Riverstyx Foundation
Contact: Roland Griffiths PhD
This study is being done to find out if psilocybin can produce personally and spiritually meaningful experiences in cancer patients, thereby extending findings from an earlier study in our laboratory with healthy volunteers. This could be important because spirituality has been associated with increased psychological coping and decreased depression in serious illness. The study will enroll about 44 people, who will receive careful preparation and 2 sessions in which they will receive psilocybin. Structured guidance will be provided during the session and afterward to facilitate integration of the experiences.
Last updated: Wed Mar 4 2009
To learn more about this study, visit the study website: http://www.cancer-insight.org
Psilocybin in the treatment of cancer patients
Investigator: Charles Grob, MD, UCLA-Harbor Medical Center - Torrance, CA
Contact:
Web: www.canceranxietystudy.org
Sponsor: Heffter
Grob has prepared a study investigating whether anxiety in the dying can be significantly reduced by the appropriate administration of psilocybin. Any attendant reduction in pain will also be measured. This study has enrolled 12 participants and all participants completed the study. The study is no longer recruiting participants.
Last updated: Tue Jan 6 2009
Effects of Psilocybin on Healthy Volunteers
Investigators: Roland Griffiths PhD, William Richards PhD, Una McCann MD, Robert Jesse
Sponsor: NIDA, Council for Spiritual Practices, Heffter Research Institute
Contact: Roland Griffiths PhD
A series of studies is planned to investigate the effects of psilocybin in healthy volunteers. The first was a double-blind study evaluating the psychological effects of 30 mg/70 kg psilocybin relative to methylphenidate, 40 mg/70 kg administered under comfortable, supportive conditions to 36 hallucinogen-naive adults reporting regular participation in religious or spiritual activities. After psilocybin, 61% of the volunteers met pre-established criteria, as measured on standardized scales, for a full mystical experience, and 31% reported significant fear sometime during their psilocybin session. Two months after sessions, 71% of the volunteers rated their psilocybin experience as among the five most "spiritually significant" experiences of their lifetimes. Seventy-nine percent of volunteers rated that it had increased their current sense of personal well being or life satisfaction. Community observer (family, friends, coworkers) ratings tended to confirm this. Fourteen month follow-up data is being analyzed.
Continuing support for this research program is uncertain and the investigators are attempting to network with individuals or foundations that could help provide support. Learn more about this research: http://www.bpru.org/jhscrp_letter.pdf
Last updated: Fri Aug 1 2008
Psilocybin Effects on Attention, Perception and Cognition
Investigators: Franz Vollenweider MD, Olivia Carter PhD, Felix Hasler MD
Psychiatric University Hospital, Zurich, Switzerland...
Contact: Franz Vollenweider MD
Sponsor: Heffter
Dr. Vollenweider and colleagues continue to study the neural correlates of consciousness and the effects of psilocybin on visual perception, attention, working memory, and time perception. Other studies will use EEG or positron emission tomography (PET) imaging.. Several published reports describe research findings, and other reports are forthcoming, or studies are underway at present.
Last updated: Fri Apr 13 2007
- Carter OL, Pettigrew JD, Burr DC, Alais D, Hasler F, Vollenweider FX. (2004) Psilocybin impairs high-level but not low-level motion perception. Neuroreport 15:1947-1951.
- Carter OL, Pettigrew JD, Hasler F, Wallis GM, Liu GB, Hell D, Vollenweider FX. (2005) Modulating the rate and rhythmicity of perceptual rivalry alternations with the mixed 5-HT2A and 5-HT1A agonist psilocybin. Neuropsychopharmacology 30: 1154-1162.
- Carter OL, Burr DC, Pettigrew JD, Wallis GM, Hasler F, Vollenweider FX. (2005) Using Psilocybin to Investigate the Relationship between Attention, Working Memory, and the Serotonin 1A and 2A Receptors. J Cogn Neurosci 17:1497-1508.
- Wittmann M, Carter O, Hasler F, Cahn BR, Grimberg U, Spring P, Hell D, Flohr H, Vollenweider FX. (2007) Effects of psilocybin on time perception and temporal control of behaviour in humans. J Psychopharmacol 21 50-64.
- Vollenweider FX, Csomor PA, Knappe B, Geyer MA, Quednow BB. (2007) The effects of the preferential 5-HT2A agonist psilocybin on prepulse inhibition of startle in healthy human volunteers depend on interstimulus interval. Neuropsychopharmacology. 2007 Published online before print.
Experimental Studies on the Effects of Psilocybin on Binocular Depth Inversion, Binocular Rivalry, Neuropsychology and Synaesthesias
Investigators: Torsten Passie M.D., Jrgen Seifert M.D., Udo Schneider M.D., Hinderk M. Emrich M.D., Ph.D.
Medical School Hannover, Dept. of Clinical Psychiatry and Psychotherapy, Hannover, Germany
Contact:
Web: www.schamanismus-information.de
Sponsor: MAPS/Medical School Hannover, Dept. of Clinical Psychiatry and Psychotherapy
This is a randomized, double-blind, active placebo-controlled study of the effects of medium doses of psilocybin in 12 healthy physicians, examining the effects of psilocybin on different neuropsychological measures, perceptual changes, synaesthesias and some subjective effects. These measures include binocular rivalry (different, or conflicting, information presented to each eye) and the "hollow mask" paradigm, measures examining changes in central processing of visual perception. The study is fully approved. MAPS has donated $3,000 for the purchase of 250 milligrams of psilocybin, insurance, and other expenses. Six of twelve subjects have now been enrolled in this study. So far, subjects have not experienced any complications. The setting is designed so that subjects have some quiet times for self-exploration. It seems that they have had some healing passages in their experiences. Our plan is to complete the study in the second half of 2007.
Read more about this study
Last updated: Fri Mar 9 2007