I once told a religious friend of mine that the difference between Christianity and Science was that Science tries to prove itself wrong.
He laughed.
"That's not true."
Okay. Why did he say that?
Without falsifiability science cannot test hypothesis or perform experiments and discover or verify.
Religion relies on a book and interpretions by men about the book.
The book doesn't really exist except by assertion. (No original uncorrupt autograph texts nobody thought to keep for verification purposes!)
Science is as close as we can get to best method of epistemology.