Puh-leeze! That's easy. "42" is the Ultimate Answer to the Ultimate Question of Life, The Universe, and Everything. It is a well-known fact.
But the ultimate question which leads to that answer is still unknown. WHAT IS THAT ULTIMATE QUESTION whose answer is "42" ?
I am glad Mrs. Jones "gets it."
Estes: It's okay, "Don't panic" that you don't get it. I have challenged your knowledge and found you "mostly harmless." Many theorize that a man who knows all that is true, confirms that 42 is indeed The Ultimate Answer, and confirms that it is impossible for both The Ultimate Answer and The Ultimate Question to be known about in the same universe (compare the uncertainty principle) as they will cancel each other out and take the Universe with them to be replaced by something even more bizarre (if that has not already happened).
Just know where your towel is and we might take you more seriously.