"Your Highness"
"The Out of Towners" (with Steve Martin)
Any scene in "Iron Man 2" that has Sam Rockwell in it. He just won't shut up.
Any scene in the "Transformers" movies that has Sam Witwicky's parents in it, talking about masturbation and getting high on marijuana cookies. They just won't stop ruining the plot.
Those are the two that stand out. I actually think the JW drama videos are pretty darn good comedy, better than a lot of actual comedies, so I'd hardly put them on the list.
--sd-7