As someone who has finally returned to university to pursue my abilities, I can agree that WT's destruction of personal abilities and ambition are a real problem. Actually, I think the things you list first in your post are what lead to the type of mind-numbing that results in what you term "the real problem."
Regardless of whether it was 1975 prophecies or the current "the end is coming soon", that is one of the tools they use to convince sheeple that pursuing their talents and abilities is a waste of time.
"If somone wants to be a doctor, actor, nuclear physisist, singer or whatever, that one is discouraged about that and is only encouraged to pioneer, i.e. get 70 hours in the door to door to support the organization."
I know my mom has told me that I could have been anything I wanted, but I pioneered and went to bethel as a personal decision rather than going to college, getting a career, and having a family. The primary defense I have is to point to the publications that promised that armageddon was coming within 70-80 years of 1914. It wasn't a "personal decision", it was a terrible decision based on terrible information disseminated by WT and pressure applied by the collective JW organization of the time. And I reminded her of the publications and talks demonizing "higher education" during the era that I graduated, praising singleness and childlessness. And I reminded her of how shocked and disappointed everyone, including her, was when my sister decided to get pregnant when the end was soooo near. That niece is now in her mid-20s.
So for me, I can completely agree that WT destroying personal abilities and ambitions is terrible. But I see that their false prophecies have been a primary method of accomplishing that task. So, I can't ignore or separate those two issues.
"Also, the 144,000 and 'two classes' with memorial partaking, and child abuse are not issues with this religion."
I see these as huge issues, also related to your "real problem." Again I'll talk about my mom's thinking because she is so terribly infected with the thinking that "the organization is the only thing that matters." Due to the 144,000 teaching, she feels that she can't really have a personal relationship or understanding of god without the FDS. JW teachings have poisoned her to accepting the idea that Jesus is the only mediator between God and humans, thinking that she must obey this corporation because they claim to be channelling god. She feels that it's important to blindly accept whatever is in the lastest WT ragazine because it's coming from god... but there is a crack in that dam.
And the child abuse issue is a huge sticking point in her mind. She is completely opposed to their policy on the elders calling the branch first rather than calling the police. In her mind, even she realizes that their priority of "protecting the organization" rather than protecting children is too far, and completely indefensible to her. And that is a crack that I'm able to widen to agree that their policy against "higher education" is also indefensible. JWs always have to run to doctors and lawyers, and where would they be without the engineers that design cars, buildings, electrical systems, etc.? Mom hates the memories of the "good old days" as she was raised in poverty and can't imagine going back to living without plumbing, electricity, cars, etc. Granted, mom's still a die-hard dub, but those cracks are enough to keep her from shunning me or turning me and my siblings in for apostacy!