1. 2,000 to 5,000 deaths plus countless thousands deprived of their possessions and their homes specifically because they were Jewish or thought to be relapsed New-Christians (who had reverted to Jewish ways).
2. The inquisition was instituted under the authorisation of Pope Sixtus IV. Here's a quote:
Thus it befell that by order of the Catholic Sovereigns their Orator at
the Pontifical Court, D. Francisco de Santillana, applied to Sixtus IV
for a bull that should empower Ferdinand and Isabella to set up the
tribunal of the Inquisition in Castile, to enable them--as Bernaldez
puts it--to proceed to the extirpation of heresy “by the way of
fire”--_por via del fuego_.
I'm not particularly anti-Catholic, but to say that their history is one of promoting human rights for all people is just wrong.