Can I tell you something really fascinating that happened to me after two days on drugs. I realise theres people here who are definately not into drugs and probably don't want to hear, and one day I will post a story why I am against certain drugs, particularly alcohol. But anyway.
An interesting thing happened to me after staying awake for 2 days on amphetamine. As I had been taking it for several weeks, the adrenaline rush that makes you run round doing things had gone, and just my mind was working overtime. I sat in an arm chair feeling slightly paranoid when I suddenly left the chair and moved through the ceiling. I was able to see the sub-strata that made up the ceiling, the inside of the wooden beams and the insulation etc. I was pulled straight back into the chair as I was so scared. Later my feild of vision was broken down into polygons, Everything I was seeing was segregated into discreet objects which didn't always relate to objects as you know them in real life... part of a shelf with it's shadow with part of the adjoinming wall would form one large polygon, which could be seperated and would "drift off" into the wrong place. I found this element of drug taking fascinating. Needless to say, these curious side effects are the only thing I gained from the experience, I do not believe the net effects of some drugs to be beneficial at all.