Village idiot The Bubonic/Pneumonic plague pandemics of the 14th century killed 1/4 of the population throughout Eurasia in the first sweep. There were four other pandemics in a 100 year period. I mention this example not merely because of its large numbers but because of the large percentage of the population affected.
Yes if you want utter human misery the 14 th century takes the biscuit, mass graves, agonizing death & all easily cured with a dose of antibiotics!!!
Which century would you like to live in ?would be my reply to your mum!