Stephen Pinker's "The Blank Slate" provides an insurmountable obstacle to Marxism. It isn't written for that purpose but he proves conclusively that we possess an innate human nature. Marxism has to assume that humans are blank slates that can be moulded to act against their own interests.
When this impossible project fails those who will not comply must be eradicated.
Even apart from Marxism so much harm has and is being done based on this absurd ideology.