Well, the Red Sox won it all last year, and nothing happened; therefore the "end" must be tied up with the fate of the Cubs.
On a slightly more serious note, it's hard to tell what will happen. There's been other "ends" in the past - mass extinctions, for example. Will mankind face some similar fate in the next 100 years? Darned if I know, but my biggest worry is some radical terrorist nutjob getting hold of nukes and doing a number on somebody. But even if that happens, I doubt that an "end" could be brought about by one or two nukes. In many respects the threat was greater when the US and Soviets were hostile enemies and were pointing all that stuff at eachother (which, btw, the US and Russia are still doing, just without all the "enemy" bluster).