Gypsy,
You will love France. Finding someone who speaks English in or around Parish or the larger cities shouldn't be a problem. Off the beaten path is another matter, as the French very Fracophile (they love their language and heritage). Carry a small English to French book with you that includes most of the common types of things you will need to ask for, etc. It was very helpful as we simply pointed in the book to what we wanted on many occasions. We found the French very helpful and friendly towards Americans (as expected), unlike some of the stories you hear.
As long as you are nice, respectful and considerate of your hosts they will likely return it. Driving in France wasn't difficult, but since rail, buses, etc. are so good likely not necessary. I rented a car and drove all over the S and E of France, without any problems. Signage is very good and driving is on the right as in the U.S. I don't think I ever saw an intersection; everything was roundabouts (traffic circles). That adds a little stress because you have to multi-task (driving into the roundabout while looking at the signs to determine where you are going as opposed to stopping at an intersection and giving it the tourist previews).
The food/wine in France is amazing. Visit some wineries if you can. Hotels, apts., etc. often don't have air conditioning, even when by American standards they should!!! So inquire about this if you are going during a warm period. Have a great trip!