I don't know about destruction of the earth-I think that a virus/viruses will take out a large proportion of the world. The Spanish Flu did a number on us back in the early part of the century. Other (past)diseases have taken out as much as 2.5% (maybe more) of the known population. It harmed more than 25% of the US population, reducing life expectancy by 10 years. Look what 'new' diseases did to the American Indians in the last few hundred years.
Interestingly, this may alleviate some of the other harm-overpopulation, which uses up resources faster than they can be replenished, in some cases. If in 1919 or whenever the Spanish Flu could do as much damage as it did, without rapid air travel, interstate highways, etc., I think a new strain of disease could do infinitely more damage-not unlike the human toll we imagine for a great nuclear incident. There will be people left, but far fewer and with a more limited capacity to destroy their own world. I hope I am wrong!