It makes all the difference in the world. Do you really think the blood of a created creature could pay the price of all man's sin. Every sin that has ever been commited and ever will?
Matthew 26:28 For this is my blood of the new testament, which is shed for many for the remission of sins.
John 6:53 Then Jesus said unto them, Verily, verily, I say unto you, Except ye eat the flesh of the Son of man, and drink his blood, ye have no life in you.
Acts 20:28 Take heed therefore unto yourselves, and to all the flock, over the which the Holy Ghost hath made you overseers, to feed the church of God, which he hath purchased with his own blood.
God's blood.
Jehovah's blood.
Where observe, The divinity of Christ asserted; he is expressly
called God, in opposition to the Arians, and their unhappy spawn,
the Socinians, who will allow him to be only man; but then his blood
could never have purchased the church, which it is here said to do,
being God and Man in one person: Man, that he might have blood to
shed; and God, that his blood might be of infinite value,and
inestimable preciousness when shed.~Burkett