God, Yeru I truly feel for you and your wife. This is classic bipolar manifestations. Unless you have lived with someone like this you just can not begin to understand the rollercoaster ride. I am sure she is sorry and she does want to come home. Her high is wearing off. THis is a very misunderstood illness and often misunderstood by the person who has it, plus add the other disorder you said she has and no wonder she is in a mess, without the meds. I totally agree since things have gotten so out of control for her, she really needs the meds and counseling. Have you thought Yeru, of having her put in the hospital for this. Many times a bipolar person, gets so out of touch with reality and off the meds they need to go in to , to get the meds right, often in high doses at hospital , and they can begin her counseling right there. I think what you are doing is very kind to her, she probably can't admit that you are doing this for her own good, but later when she is well she will see it. There is alot I can say about this illness, I am sure you know it very well, it is a tricky one. ALot of bipolar people do not want to stay on their meds.
Anyway, if you think a temp seperation , that may turn out perm. might be in order, putting her in a hopsital, with a good mental health facility would be a great way for her to use her time while not at home.