Nice question cassi;
Alan has answered a lot of your questions, but there's a few questions you asked I'd still like to respond to;
If we had allowed natural selection to take place how much different would this planet be?
Has man interfered with the natural selection perhaps making critical mistakes which will assure the end of humanity quicker then allowing those weak ones to expire?
First we have to define the paramaters of that; for the ease of explanation, let us assume that humans diverged into two species, us and 'Klingons'.
There's no need to explain what the 'us' would be like, as we're it. But our cousins, the 'Klingons', would be as technologically advanced a race as us, but would believe 'weak' children should die, leaders should be replaced when they can no longer defend their position, and that deformity and infirmity were shameful and intolerable.
Obviously in such a spartan society, overall levels of physical fitness would be higher as those without it would be culled by sociological processes, so, yes, modern human society has made us physically weedier than we otherwise could be. Modern H sapiens is far weedier than some pre-sapiens and some ancient sapiens; Neanderthal's, for instance, are stocky and thick-boned as a rule; you really wouldn't want to get in a fight with one. I have a good level of fitness, but in any society without the technology to make spectacles I would be dead unless I had found a niche where my appaling eyesight didn't make me a liability or easy game for accident or predation.
However, that doesn't mean that 'Klingons' would win if they and us came into conflict over resources. A snake is physically weedier than a lion, can move less quickly, is a solo hunter, has short-range eyesight... but if it's a poisonous snake, physical strength doesn't come into the equation (this is just a loose example of 'the stongest doesn;t always win the fight).
By developing 'culture', humans have a meta-inheritance to pass on as well as a genetic inheretance to pass on. This non-genetic transferrable information can make an individual organism in that society and a society of that organisms more succesful in passing on genes than it would do if there was just genetic information.
Obviously in this thought experiment 'Klingons' would also have culture and all the benefits it brings too, but just having a culture that retained selection factors for strength and natural health doesn't mean that overall levels of reproduction would be higher, or that their culture would be more successful than ours in direct competition.
What man has done is, first, introduce non-genetic tranferable information that aids survival. Some other species do this a bit, but none approach the scale with which humans transfer information between generations. Culture has become part of our evolutionary inheritance, and the evidence that it works well (aloong with the genes) in making gene survival machines is that we are naked, weak, slow... and the most successful large organism on the planet.
The advantages given someone by having a strong, fast, healthy body do not mean they will neccesarily have more children that the 140lbs short-sighted geek with a concave chest, or that cultures where one lot is healthier than the other would automatically triumph in a conflict.
Now man is developing the ability to change what genetic information gets passed on. This is something that at first will be applied to lethal genes, like MS, or severely disabling syndromes.
Just as using corpses to extend medical knowledege was considered 'wrong' by most people three hundred years ago, and organ transplants are still considered wrong by some, so too shall the negative feelings regarding genetic manipulation receed.
I don't think we will have potential problems with superbeings, at least in terms of intelligence... it seems that it will be quite a while before we understand how intelligence works and it's nture-based as well, not just a sequence of genes. What we will potentially have in the future is people with good eye sight, robust immune systems, and no-genetic diseases or genetic prediliction to disease.
There's also people that think the best way to get people with long-lifespans is to breed for it; we have never had any selection pressure for robust and extended old age; we have had selection pressure to be able to reproduce and raise kids. If a group of people started an organisation, such as featured in Heinlein's books, where people with very old grandparents and parents bred, then we'd likely see quite rapid increases in their children's average lifespans, as we'd be stacking the "deck of genes" with genes that worked well in old bodies.