Marburg and Ebola viruses? Man made? (page 3)

fleaman uk

The DOD has hundred of top secret projects involving tens of thousands of people - effectively silenced. EG. Area 51.

Hee hee...nuff said eh Chaps?

Abbadon - you are so ferociously keen to scrap, that your impatience shines. You obviously are not running companies worldwide, while maintaining several households, while embroiled in litigation and employing myriads of people. So your discontent with my schedule and my inability to write EF-like dissertation, must prove a helluva frustration. Tough! Verbosity substantiates nothing.

Gaant je goed jonge!

Stephen John Gault

Abaddon - You mention two seperate problems, one concerning syphylis, the other industrial waste. These were county level with some State/National involvement. With respect, to use these as examples, when you are alleging possible conspiracy regarding HIV or filoviruses, is really not providing comparable examples.

I was not using that to illustrate the HIV hypothesis, but demonstrating the abusive averices of government. Read again. If you are as intelligent as you attempt to assert, surely you, like everyone else, would have understood that. Junkyard dog mentality comes to mind.

Abaddon

SJG

You obviously are not running companies worldwide, while maintaining several households, while embroiled in litigation and employing myriads of people. So your discontent with my schedule and my inability to write EF-like dissertation, must prove a helluva frustration. Tough! Verbosity substantiates nothing.

Oh, let me quiver at your greatness. LOL. I don't NEED to substansiate ANYTHING, don't you get that? YOUR the one who needs to substansiate things. I've made no claims, just questioned yours (with no substansive answer from you).

And the precious time you have given us has been rather poorly used.

You have evaded answering a simple question; how have you excluded these virusus from having developed naturally?
In your last post you make a straw man argument; I did not say you used Tuskeegee and Love Canal to "illustrate the HIV hypothesis". You were using them to illustrate cover-ups happen. You make this straw man even though you actually quote me in your post;

to use these as examples, when you are alleging possible conspiracy regarding HIV or filoviruses, is really not providing comparable examples.
You make another straw man argument when you respond to me "Tuskeegee experiment? Call that evolution? "; I made NO connection between Tuskeegee and evoltuion.
You make no response to me pointing out your comparison of a short term wartime project which was then made know worldwide knowledge overnight (Manhattan) is ANOTHER example of a cover-up that you cannot compare to a long-term, peace-time, vast interternational effort that has been known about publically since the very begining.
And your continual appeals to your own authority are a new twist on an old logical fallacy.

Given the small amount of time you can give to a topic you started, it might help if you responded to questions. If you stopped making straw man arguments, and cut down on the invalid comparisons, you might find time in your busy schedule to do this...

Black Sheep

I go with Ebola being an old virus. There were effective traditional protocols for quarantine in the event of an outbreak. These protocols would have been developed from the experiences of previous outbreaks.

Just my .02 worth

Chris

Stephen John Gault

Abaddon - read again. I did not posit as an authority. I asked if anyone had inside info.

Lets start here - Are you aware of any, any man made virusus? What? Where? When?

Abaddon

Never mind SJG.

It obviously doesn't matter much what people say to you, judging from your response. I think "green cantalope marshmellow chicken" would evoke the same response as something relevent.

I did not posit as an authority.

Thus you telling us how wonderfully busy and imprtant you are is something you do normally?

I asked if anyone had inside info.

And as has been commented on, the fact you think this is a likely place to find 'inside info' calls your judgement into question.Have fun with the thread. There's just SO MANY ex-JW molecular biologists...

PhiX has been duplicated, Polio has been duplicated, as in assembled from non-living components and made 'living'. Man-made and man-altered are two different things however. But I think you'd be happier doing research at www.rense.com...

outoftheorg

SJG

You are your own worst enemy.

Stop telling us how great and knowledgeable you are and you may find a place in the world for

yourself.

Nobody needs to know how many businesses you are in charge of or how many households you control and how busy you are in litigation.

Although I can understand how you may be facing many challenges in court.

Outoftheorg

EvilForce

The 4 distinguishable subtypes of Ebola and the single subtype of Marburg virus comprise the known members of the family Filoviridae. Controversy remains regarding the question of whether the 4 distinguishable Ebola viruses are subtypes or separate species.

Filoviruses share a characteristic filamentous form with a uniform diameter of approximately 80 nm but display a great variation in length. Filaments may be straight, but often they are folded on themselves. Ebola virus has a nonsegmented, negative-stranded, RNA genome containing 7 structural and regulatory genes. The Ebola genome codes for 4 virion structural proteins (VP30, VP35, nucleoprotein, and a polymerase protein [L]) and 3 membrane-associated proteins (VP40, glycoprotein [GP], and VP24). The GP gene is positioned fourth from the 3' end of the 7 linearly arranged genes.

Following infection, human and nonhuman primates experience an early period of rapid viral multiplication that, in lethal cases, is associated with an ineffective immunological response. Although a full understanding of Ebola must await further investigations, part of the pathogenesis has been elucidated. Most Filovirus proteins are encoded in single reading frames, the surface GP is encoded in 2 frames (open reading frame [ORF] I and ORF II). The ORF I (amino-terminal) of the gene encodes for a small (50-70 kD), soluble, nonstructural secretory glycoprotein (sGP) that is produced in large quantities early in Ebola infection.

The sGP binds to neutrophil CD16b, a neutrophil-specific Fc g receptor III, and inhibits early neutrophil activation. The sGP also may be responsible for the profound lymphopenia that characterizes Ebola infection. Thus, sGP is believed to play pivotal roles in the ability of Ebola to prevent an early and effective host immune response. One hypothesis is that the lack of sGP production by Marburg virus may explain the reduced virulence with this agent as compared to that of African-derived Ebola.

Recently, Leroy et al reported their observations of 24 close contacts of symptomatic patients actively infected with Ebola. Eleven of the 24 contacts developed evidence of asymptomatic infection associated with viral replication. Viral replication was proven by the authors' ability to amplify positive-stranded Ebola RNA from the blood of the asymptomatic contacts. A detailed study of these infected but asymptomatic individuals revealed that they had an early, 4-6 days after infection, and vigorous immunologic response with production of interleukin-1beta, interleukin-6, and tumor-necrosis factor, resulting in enhanced cell-mediated and humoral-mediated immunity. In patients who eventually died, proinflammatory cytokines were not detected even after 2-3 days of symptomatic infection.

A second glycoprotein of 120-150 kD, transmembrane glycoprotein, is incorporated into the Ebola virion and binds to endothelial cells but not to neutrophils. Ebola virus is known to invade, replicate in, and destroy endothelial cells. Destruction of endothelial surfaces is associated with disseminated intravascular coagulation, and this may contribute to the hemorrhagic manifestations that characterize many, but not all, Ebola infections.

Clinical infection in human and nonhuman primates is associated with rapid and extensive viral replication in all tissues. Viral replication is accompanied by widespread and severe focal necrosis. The most severe necrosis occurs in the liver, and this is associated with the formation of councilmanlike bodies similar to those seen in yellow fever. In fatal infections, the host's tissues and blood contain very large numbers of Ebola virions and their tissues and body fluids are highly infectious.

Presently, 4 distinct subtypes have been identified, each named for the location where it caused documented human or animal disease. Two Africa subtypes, Ebola-Zaire (EBO-Z) and Ebola-Sudan (EBO-S), have been responsible for most of the reported deaths caused by filoviruses. Clinical disease due to African-derived Ebola virus is severe and, with the exception of a single patient infected in 1994 with the Cote d'Ivoire (EBO-C) subtype who survived, is associated with a mortality rate of 50% (Sudan, 1976) to 88% (DRC, 1976). The forth subtype is Ebola Reston (EBO-R), first isolated in 1989 in monkeys imported from a single Philippine exporter. A virtually identical isolate imported from the same Philippine exporter was detected 2 years later in Siena, Italy.

Between 1994 and 1996, a stable strain of Ebola caused 3 successive outbreaks of hemorrhagic fever in Gabon (mortality rates ranged from 57-66%). Because the Gabon strain has a greater than 99% homology of the nucleoprotein and GP gene regions with EBO-Z, it has not been considered a distinct subtype.

To date, no reservoir has been identified for any Filovirus. However, in 1996, members of the National Institute for Virology of South Africa went to Kikwit, Zaire (now the DRC) and evaluated the infectivity of Ebola for 24 species of plants and 19 species of vertebrates and invertebrates. Insectivorous bats, Tadarida pumila, and fruit bats, Epomophorus wahlbergi, were found to support Ebola virus replication without dying. Furthermore, serum Ebola titers in infected fruit bats reached as high as 10,000,000 fluorescent focus-forming units per milliliter, and feces contained viable Ebola virus.

Stephen John Gault

Thanks EF - can you cite your source please.

Marburg and Ebola viruses? Man made?

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