Leftie here! Congratulations, we are wonderful people.
Yes, there are some things that you should know about care and feeding of your lefty.
1. Lefties are not just righties using the other side. Their brains are different, not simply reverse images. You see, very few lefties are as 'left-handed' as righties are 'right-handed'. That is to say, most lefties will do some/many things the same as a rightie. I've heard it referred to as 'mixed leftie.' I play racquet sports with my left hand. I throw with my right hand. I write with my left hand. I do most 'strength' moves with my right hand.
2. There are some things you can do that will make life easier for him. Look for his dominant features. See which leg he pushes off when he starts running. That is the hand you wnat him to throw from. That is the hand you want him to hold a racquet in. Let him decide which had to use use for the small, detailed moves like writing, painting etc.
3. Learn how to determine his dominant eye. That will help determine which shoulder you want him to holld a baseball bat on, which shoulder he needs to hold a bow on, or shoot from, or anything else that requires aiming. It is a simple test that involves merely looking at something distant though a small hole and seeing which eye he goes to naturally.
4. If he writes with his left, you need to get him some specialized help. You see, you righties get to draw away as you write. Lefties need to push into the letters. That is why lefties grip so hard. That is also why they tend to develop strategies that look so awkward - things like hooking their arm around, or writing straight up or straight down. My mother, a leftie, has beautiful handwriting. But she looks like she's dislocating here arm as she hooks around and writes straight down. I think a good way is to teach them to write straight across, from uinderneath the line. This leaves no slant on the cursive writing. But, once learned, it is easy and neat. I have horrible handwriting.