I think it depends on how the "lost" part happened.
When I broke up with my ex, it was a terribly depressing and angry time for me. He'd lied to me about some terrible things. At the time of the breakup, I was devastated, suicidal even.
Today I'm in an amazing relationship with the best man in the world. If he were to be taken out of my life instantly, I would be devastated again. But it would be different. Mozz and I appreciate every little moment we have together. If it ended today, we'd be terribly sad, but we'd be extremely grateful for the little time we've had together. Every second is a blessing. Every day I get thousands of seconds of blessings.