Well lets see. Life has been on earth for at lease 4 billion years( simple cell life) Around 2 billion years ago complex cellular life appeared. Modern humans appeared around 200 000 years ago.
There was at least 5 major mass extinctions that we know of on earth. These extinctions were cause by different things.
- Catastrophic Agents- such as meteorite impacts and comet showers,
- Earth Agents- such as volcanism, glaciation, variations in sea level, global climatic changes, and changes in ocean levels of oxygen or salinity
So it is possible that we see an other mass extinction on earth that can be biologically (humans) caused.
If we do manage to wipe out almost everything I believe that life can evolve into something else with out us being around.