I am a little confused with your analogy of God and Santa Claus. I know where the presents came from under my tree, but I have no idea how the Universe started or where it got the space to exist as it does.
I guess the point is this: can you accept that some questions are unanswered as of today and, maybe, forever -- or do you have to resort to making up an imaginary entity called "God" (who in many religions is simply a glorified reflection of people themselves) to explain your current gaps in knowledge?
A lot of old mythology revolved around attempts to explain natural phenomena, bizarre rock formations, thunderstorms etc. which used to be interpreted as the footsteps of gods or angry fits of other gods, whatever. Nice stories, sometimes really wonderful literature, but also nothing more than that. Anyone can make up a dozen fantastic stories to explain lightning, possibly starring a bunch of fairies and demons and gods. Which one is true, if any?
All this boils down to "explaining" complexity by inventing more complexity, and of course it still leaves you with the question, who created God? Even if you accept god as an explanation, you have no explanation how his existence started. The question is merely deferred, but not answered at all. And actually, book religions such as Christianity now have to spend an inordinate amount of time and effort to somehow cope with the growing gap between scientific discovery and their particular holy writ. Some people just try to find new and more metaphorical interpretations of scripture, others cling fiercely to their literal interpretations of obscure half-sentences and simply deny whatever science has to say if they sense conflict. It must not be true, so it cannot be true: welcome to the wonderful world of creationism, where "truth" is whatever we say it is.
By smoking weed or other means, one may feel absolutely certain that he's found the answers to all the deep questions. Everything makes sense, everything is connected with everything, enlightenment, satori, whatever. Once he wakes up from his high, it turns out that he actually knows zilch. He cannot explain anything at all. He may feel that he does, and that people should know and listen to lengthy, nonsensical rants with lots of fantasy figures in them, lest they be punished by some of the more powerful fantasy figures. I think this kind of experience is responsible for lots of religions on this planet. A very good reason why people should stay away from drugs :-)
To me, spirituality is just an appreciation of life and the wonders around us; science explains those things.
I like that.
f.