It's going to be different for everyone, so in order to understand it you'd have to get down to what happens inside rather than the way it shows up in people's lives.
It's like the other thread on what makes someone happy when it all seems empty, it's going to be different for everyone at different times. And actually, even IF you do identify the specific thing for you or another specific person, if you focus on that too much you may not see the inner movement.
But I guess most people really want comfort, which is great in a time of need - but is ultimately only a band-aid. Depending on the wound it can either heal itself, or something else may need to be done so that it can be healed. If you have a bullet or some foreign object in there, you'd want to find it and dig it out.
So step one, stop looking on the outside, the surface of the wound. This includes relying on standard psychological theories without inner exploration, because that is only a general map and you need to find out what's going on in the geography of your mind.