My father is bipolar.
My father's father was perhaps bipolar but undiagnosed, may also have had Asperger's Syndrome.
My father's father's brother (dad's Uncle) was "in and out of mental institutions" all his life. No known diagnosis.
My father's grandfather committed suicide. No known diagnosis.
My father lapses on his meds often. His narcissism becomes pronounced. He has suicidal ideations without the meds.
I went through years of meds with therapy to combat depression and anxiety (diagnosed). These days I am pretty aware of gentle mood swings (usually down, but occasionally manic) that are out of proportion to what's going on in my life, but they have been manageable - I can control the manic part so that the only consequence is a heightened extroversion (I'm normally very introverted). I generally meditate in the evening.
I am fairly sure that without the meds and the therapy I would probably not be alive today.