It means "shrewd" in the sense of "prudence" in clever knowledge and sight, usually in navigation.
It almost sounds like the Bible wasn't quite so black and white when this was written. (Ie not the later idea of absolute evil and good)
Because - well - the snake was right. "In that day" they absolutely did not die, they died much, much later. And they did afterward know right from wrong, or good from bad.🤷🏼♀️
I like the explanation of TWOT:
😂Funny acronym