Intriguing stuff pale.emperor!
Two thoughts come to my mind...
According to Christians who embrace biblical doctrine as the final authority, the fall leading to imperfection may have caused degradation, harmful changes/mutations. A very, very cruel concept of course and what a bizarre intention to make it last for 6000+ friggin' years! But hey, who am I? A worm...
From an intelligent design perspective,the identity of the intelligence is unknown, It could be a god/gods, a spirit creature (angel, demon, unknown) or an alien as well. If (seeded) life would have been left on earth long ago (on purpose or by accident), degradation might as well have taken place. Seeking design patterns that indicate intelligence however do not necessarily adress the problem/objection of morality. It would be like saying that the nazi's couldn't have built the V2 because they've killed so many people in concentration camps.