Don't know if this is "most memorable", but it's the first one that comes to mind.
Early 90's - the Awake cover featured a series of articles on crack cocaine, which was the big thing in the news then.
Was out in service with an older guy, a few flapjacks short of a grand slam, if you know what I mean. Also had near-zero social grace.
Walk with him up to a door, householder is working in his yard.
Householder: "Good morning, how..."
Brother No-Filter: "WHAT ARE WE GOING TO DO ABOUT THIS CRACK???"
Householder, confused, begins inspecting his sidewalk for fissures.