Daniel chapter 2 march of world powers culminates with UN as described at 2:41,41 "iron mixed with soft clay" like governments and NGOs.
Daniel chapter 7 march of world powers ten horns part, other horn before which three fell (US/UK/UN led treaties after WWs humiliated former Roman empire kingdoms of Austro-Hungary, Italy, Germany), then in verse 21 UN makes war on holy ones during great tribulation. Also described at Daniel 7:25 as "He will speak words against the Most High, and he will continually harass the holy ones of the Supreme One. He will intend to change times and law, and they will be given into his hand for a time, times, and half a time."
Daniel chapter 8 march of world powers small horn UN attack on religious institutions described verses 10-14: "It grew so great that it reached all the way to the army of the heavens, and it caused some of the army and some of the stars to fall to the earth, and it trampled them down. It exalted itself even against the Prince of the army, and from him the constant feature was taken away, and the established place of his sanctuary was thrown down. And an army was given over, together with the constant feature, because of transgression; and it kept throwing truth to the earth, and it acted and had success. And I heard a holy one speaking, and another holy one said to the one speaking: “How long will the vision of the constant feature and of the transgression causing desolation continue, to make both the holy place and the army things to trample on?” So he said to me: “Until 2,300 evenings and mornings; and the holy place will certainly be restored to its right condition.”
(Genesis shows "an evening, a morning, one day"...2,300 evenings and mornings is 1,150 evenings and 1,150 mornings, same is 1,150 days which fits within the 3 1/2 year tribulation.)
Daniel 8 again says at verse 19 "Here I am causing you to know what will happen in the final part of the denunciation, because it is for the appointed time of the end." The UN leader is described at 8:23-25 "“And in the final part of their kingdom, as the transgressors act to a completion, a fierce-looking king who understands ambiguous sayings will stand up. His power will become great, but not through his own power. He will bring ruin in an extraordinary way, and he will be successful and act effectively. He will bring mighty ones to ruin, also the people made up of the holy ones. And by his cunning he will use deception to succeed; and in his heart he will exalt himself; and during a time of security he will bring many to ruin. He will even stand up against the Prince of princes, but he will be broken without human hand."
Daniel chapter 12 is set "in the time of the end" (verse 4.) Verses 6,7 state "How long will it be to the end of these marvelous things?” Then I heard the man clothed in linen, who was up above the waters of the stream, as he raised his right hand and his left hand to the heavens and swore by the One who is alive forever: “It will be for an appointed time, appointed times, and half a time. As soon as the dashing to pieces of the power of the holy people comes to an end, all these things will come to their finish.”"
Jesus talked about the appointed times of the nations, which was referring to the attack by the governments of the nations on religious institutions during the great tribulation. "And they will fall by the edge of the sword and be led captive into all the nations; and Jerusalem will be trampled on by the nations until the appointed times of the nations are fulfilled." (Luke 21:24)
The progression of world powers in Daniel coincides with the descriptions of the US/UK breathing life into the UN in Revelation chapter 13. The time period of 3 1/2 years in Daniel also coincide with the 3 1/2 years in Revelation where the Devil comes down and causes woe on the earth.