A small percentage of people who take antidepressants will have a paradoxical reaction meaning that the meds worsen the symptoms they are supposed to be treating. I once tried to switch to wellbutrin, but it made me extremely depressed. So, I went off of it and went back to the antidepressant I had originally been taking. I have taken these lifesaving drugs for years since I was diagnosed with Postpartum Onset Bipolar disorder.
This paradoxical effect is not confined to psychiatric drugs. Some people find themselves wide awake after taking benadryl in over the counter sleeping pills. I have this effect from alcohol. I hear it is supposed to relax you, but when I drink, my anxiety spikes and I feel like climbing the walls.
The important thing to remember with antidepressants is that if it makes you feel worse, stop taking them! They often advise that it might take several weeks before they start working and to keep on taking them, but that is different than them making you feel even more depressed or even psychotic. If that happens, stop taking them immediately and call your doctor. There's likely another drug that will work better with your body chemistry.
