The positive side of our changing models for reality is that with each iteration we do gain more control and power over our surroundings. Strongly suggesting that our knowledge is at least on the right track. Newtonian classical mechanics are still quite valid and can be successfully used in our macroscopic day to day world. Quantum mechanics makes us humble in just how incomplete our knowledge really is though. But I'm still satisfied with what can be done with that limited amount.
I'm with you though that these are all models. And so I'd be presumptious to ad hock rule out any other plane or realm to reality (for this discussion that means any "spiritual" reality)