>>It not often realized that even if a self-replicating system did somehow once come into being, that any sustained life would not necessarily be a likely result. Things such as hostile environmental factors, destructive reactions, etc, make rapid "extinction" probably a far more likely result for the emergent "life" and/or any small descendent population. The saying by some that "all it takes is for life to form once", overlooks many things.
We haven't been able to recreate the event (or CREATE it, to avoid assuming it ever happened in the first place), so it's impossible to say whether the self-assembled replicators would be hardy or not. It stands to reason that an environment that allowed for their creation would not be one hostile to their continued existence, but it's only "reasoning" at this point. There's no proof.
It might be better to say "all it takes is for life to take hold once". By nature, a self-replicator would .. well,.. self-replicate. So it short order, assuming it survived those first few moments, it would have created a population of children, that would also create a population of children. There's no reason to assume it worked the first time, nor to assume that it only worked once.
That some or even most replication errors would be detrimental to survival is irrelevant, as that would lead to the error-ridden children "dying", or at least not replicating as well. It would be the general population that would sustain the growth, and the few serendipitous "good errors" that would move them toward higher life.
If it happened at all... ;-)
Dave, great-great-great[...]-great grandson of a self-replicator