Now about Prayer,,,,,,,,,,,maybe I can go a different direction in my thinking on that one.
I suggest abandoning the "thinking" part, while shifting "direction" to within.
Perhaps what you are experiencing dear, is a yearning for connection to something bigger than the shard of existence* which we commonly identify with. Often the true connection is reestablished through silent and open conscious-awareness of this present-moment.
The seeming illness of "disconnection" is a symptom of too much focus of attention on the mind's interpretation of life, and not enough attention on Life.
The mind naturally fragments, separates and categorizes life that it may acquire a sense of understanding and place within it. Unfortunately it gets to enthusiastic and often shrinks and separates a sense of self in the process. You, are not at all separate from all Life; it just appears to be that way.
What you desire dear, the Source and Sustenance which you yearn for, is closer than close; and IS what you actually are.
j
* the term shard of existence, I just recently heard from dear LittleToe; and liked it so much, I took it.