Little Toe- a good friend of mine lives in Las Cruces. She and her hubby both think it's wonderful, but pretty danged hot.
As far as I'm concerned, coastal Maine has it over the rest of the US, as far as climate and culture are concerned ( Insomniac ducks, as Country Girl hurls a Texas cowflap at her head in retribution for this insult). Honestly, up here we're comfortably set apart from the rest of the states, but still, one hour's drive south takes me to an excellent blues club ( Ray LaMontagne, anyone?), 2 1/2 hours will take me to Cambridge/Boston for the evening, and a mere 7 hours gets me into Manhattan, so we're not entirely isolated. In general, the US is a great place to live, but the farther Northeast you go, the better.
(edited cuz Insomniac cain't spell too good when she first wakes up.)