The problem with Sandford
Hello! I have read a couple of papers on Sanfords model of evolution (Mendels Accountant) where he test his hypothesis that darwins first axiom is wrong. . .
Why this is bullshit:
One can make many theoretical objections to Sanfords model, or indeed just show him examples that the very ting he says his program show is impossible, that positive mutations are selected for, actually happends in nature. Here are a couple of links:
http://www.nature.com/nature/journal/v413/n6855/full/413514a0.html
http://www.nature.com/nature/journal/v419/n6909/full/nature01140.html
http://biology.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pbio.0030170
http://www.nature.com/nature/journal/v437/n7055/full/nature04072.html
http://biology.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pbio.0040072
http://scienceblogs.com/evolgen/2006/03/detecting_natural_selection_pa.php
Actually his program allows for the selection of positive mutations. As far as the links that you provided, the main problem with them is that they often start with the assumption that humans, chimps, and other apes share a common ancestor to begin with, and that humans evolved from this ape like ancestor over million of years. (the assumption of the evolution in question), Then based on this primary assumption and other secondary evolutionary assumptions attempt to detect “positive selection”. Even these secondary assumptions are questionable.
http://www.discovery.org/a/14251
Biologist Austin Hughes warns that most inferences of positive selection are based upon questionable statistical analyses of genes:
A major hindrance to progress has been confusion regarding the role of positive (Darwinian) selection, i.e., natural selection favoring adaptive mutations . In particular, problems have arisen from the widespread use of certain poorly conceived statistical methods to test for positive selection. Thousands of papers are published every year claiming evidence of adaptive evolution on the basis of computational analyses alone, with no evidence whatsoever regarding the phenotypic effects of allegedly adaptive mutations. … Contrary to a widespread impression, natural selection does not leave any unambiguous ‘‘signature’’ on the genome, certainly not one that is still detectable after tens or hundreds of millions of years. To biologists schooled in Neo-Darwinian thought processes, it is virtually axiomatic that any adaptive change must have been fixed as a result of natural selection. But it is important to remember that reality can be more complicated than simplistic textbook scenarios. … In recent years the literature of evolutionary biology has been glutted with extravagant claims of positive selection on the basis of computational analyses alone ... This vast outpouring of pseudo-Darwinian hype has been genuinely harmful to the credibility of evolutionary biology as a science. 19
Austin L. Hughes, "The origin of adaptive phenotypes," Proceedings of the National Academy of Sciences USA, Vol. 105(36):13193–13194 (Sept. 9, 2008) (internal citations removed).
Regardless of the above, as I stated earlier the main problem with citing these sources for this issue is that they often automatically assume that human evolved from ape-like creatures over millions of years, to begin with. Hence, while they may be useful within the evolutuionary paradigm, they are essentially useless as evidence against arguments designed to test the validity of the evolution story to begin with.
I can easily make a program that validate evolution, heck, lets write it right now:
1) Initialize a population of 1000 individuals, each with a fitness of 1.
2) (mutation) Add a number uniformly distributed from (-1, 1) to each individuals fitness.
3) (replication) Delete the 500 individuals with lowest fitness. Copy them to get to 1000 again. Go to 2).
but that does not prove jack shit because i have not validated it against reality.
Interesting, since this is actually similar to the operation of the pro-evolution computer simulation that you recommended on this forum (http://www.jehovahs-witness.net/jw/friends/183269/2/Mitochondrial-Eve-for-dummies )
“The organisms are subjected to rounds of selection and mutation.First, the number of mistakes made by each organism in the populationis determined. Then the half of the population making the leastmistakes is allowed to replicate by having their genomes replace(‘kill’) the ones making more mistakes.” http://nar.oxfordjournals.org/cgi/content/short/28/14/2794