Depends on what it says. If there is clear evidence of criminal acitivity, yes. By this I mean so obvious even the Republicans will have to acknowledge it. That is what brought Richard Nixon down, and gave Bill Clinton a pass. Nixon's problems became so big even his own party had to repudiate him. Clinton was able to make the charges look fuzzy enough to give Democrats supporting him cover to let him stay in office. (Side note, the Clinton affair can be taken as proof that lying under oath is not an impeachable offense, neither is hitting on an intern in the oval office,)
If Mueller can't find anything really big, it won't matter because the Democrats will just go look for something else to charge him with.