I was initially prescribed Prozac, but it's effects were not pleasant. At first, I became suicidal, which I wasn't before. So the psychiatrist upped my dosage. Then, as mentioned in previous comments, I turned into a zombie. People would be laughing around me and I would just sit there with my eyes glazed over. I would drive places and not remember how I got there or where I parked my car. I was sleepy all the time. Once I drove to the store to get groceries and then rested my head on the steering wheel after I got there because I was so tired. Next thing I know, I woke up after midnight, it was dark outside, the store was closed and my car was the only one left in the parking lot. On top of all this, the sexual side effects were intolerable.
A close friend of mine had been on Prozac but said it turned him into a zombie, so he quit cold turkey. I considered doing that, but a breakup with my boyfriend and my mother's death drove me to another major depressive episode, or "nervous breakdown" as they used to be called. A friend got me to a doctor who took me off Prozac and put me on Wellbutrin. It worked great! No zombie feelings and my sexual desire and stamina were back. Not only that, Wellbutrin is often prescribed to curb hunger, so there was no weight gain.
After a couple of years on that, the depression was greatly diminished -- I don't know if it ever goes away 100% -- but I still had very dark sadness over any death-related events, entertainment or news. A new psychiatrist did a more thorough examination and found I had both depression and post traumatic stress disorder because of my work and recent personal experiences with the death of several close friends and family members. So I was put on Pristiq to treat both conditions. The meds seemed to work better for a couple of years, but then my doctor moved away and I had a hard time finding a new one who would prescribe me more meds without a lot of examinations. So I gradually weened myself off of the drugs and I've been drug-free for about three years now.
I can feel the depression there at the door, so to speak, but I try hard not to let it in my life. I try to get exercise regularly and I take vitamin B (Super B complex) daily to help regulate my mental health. So far, so good. It also helps to talk to others you're close to so problems don't build up. This seems to work for me, but I know I'll probably have to go back on meds if depression returns for more than a couple of weeks. But I'm good for now.