When they're all old, sick, in a nursing home I'll simply walk in, ask them if it was worth wasting their whole life shunning their family members instead of enjoying the little time you get with them. I'll then remind them that in actuality, we only get one shot at this life and that I hope they are happy with how they spent there's.
I take it that you don't like your family that much.
I guess it is pretty easy to shrug off rejection if you already despise the ones rejecting you. Understand, however, that most of us actually like our family to some degree.