Before the issue of sovreignty came up between God and Satan, humans were in a perfect state. Then Adam and Eve sinned, and Satan challenged God's right to rule. God took Satan up, and allowed humans a chance to prove that they could govern themselves, independent from him.
But first he inflicted them with sickness, death and imperfection. In essence, he stacked the deck against humanity so that they would fail. Couldn't humans have fared better in living apart from God had he left them in the state in which he created them?