Or something bad will happen to them without any spell or curse? Just curious how you'd view that...
My personal take on this, is that the biggest "curse" that people like that can have is just being themselves. Negative nasty people fill their lives with negative, nasty energy. If you 'curse' them, there is a chance you will be involving them in your lives even more. Most I know believe curses bind the curser and the cursee somehow. Better to get farther away than closer. You can't fling tar and feathers without some of it getting stuck on you.
The most I have done is do rituals, etc, designed to "reflect" their nastiness back onto them, and not affect you (use mirrors and teflon ). Make up your own (such things are best when they work with your own ideas)...the best "spells" or "workings" or whatever you refer to them as, use signals to your own subconscious rather than 'recipes' out of a book that mean something to someone else. Visualize your home as having a "mirrored bubble" around it, that will allow only pleasant things in and reflect nasty thoughts etc back at the sender. Do fun and inventive things in a ritual. You'll feel better. If you have to be around them again (may I suggest a motel for next time?), do a ritual where you use some sort of reflective jewelry or something, to do the same thing. (edited to add...and then wear the jewelry the whole time you are in their company)
I have, in extreme circumstances, asked the "powers that be" (PTB) to turn their attention to people who have really done awful things and should be punished (one pagan group I know did a ritual in which they "shined a light" on an unknown murderer to try to bring them to justice...it was really recent so the case is still ongoing). There are goddesses who specialize in retribution, you know. For instance, the Hindu goddess Kali has a reputation for seriously disliking men who abuse women. The Egyptian goddess Sekhmet (the lioness) is another protector/destroyer. But I wouldn't in a million years mess with them over something as minor (even tho annoying) as your family pissing you off. Things like that must be handled very carefully and delicately.
If they upset you and anger you so much, why focus on them even more? Point karma, or the PTB, or "the universe" in their direction and wipe your hands of it. Certainly the best outcome for you would be not having them affect your life anymore. Which reminds me...when you do a ritual, you then have to 'act in accord'...so women who do rituals to remove abusive men from their lives and then turn around and let them back in their house, for example, are not likely to achieve great success in their ritual.