I have to agree with ya Iron, based on my own experience of course. I can "handle" one martini, or maybe two glasses of wine with a hefty dinner. If I go beyond that, I usually get very depressed and weepy...jezz what fun. If I don't get depressed while drinking (which I can do if I really space my drinks out) usually the next day I'll be depressed.
I have taken several college courses on alcoholism and chemical dependency, thinking I might go for a degree in counseling. I was taught (around 18 months ago) that women have less of the enzyme that helps metabolize alcohol than men. So in women, alcohol tends to go straighter into the blood system, especially as we age or abuse alcohol.