I have been in the big-D since 2010 - 30 + months of dark hell.
Was first put on a combination of paxil and Molipaxin?? which turned me into a Zombie and i tried suicide twice.
Then Ciprilex - no change
Now on Effexor [Venlafaxine] and it kicked in within 3 weeks and I am now in "remission" "
Please note : you gotta work out your own modality but it will have to be multi-leveled ie Psychology / Psychiatry / Exercise / CBT / family support etc etc
I was dead scared of going on with meds after the Paxil episode but the Effexor is working - However I believe it is a "bitch" to come off. I forgot to take it a few times and within 6 hours I was dipping and getting "brain-zaps"
And ......................not being involved in religion was one of the biggest +'s toward recovery !
Actually when I was truly in "the Vale of Deep Shadow" with the D NOT ONE of my fellow elders even came to visit me !
It got me heading for the door more rapidly.