Was A Cancer Cure Quietly Eliminated?

by metatron 68 Replies latest jw friends

• 

  botchtowersociety

  http://www.ncbi.nlm.nih.gov/pubmed/21454232

  Mebendazole monotherapy and long-term disease control in metastatic adrenocortical carcinoma.

  Dobrosotskaya IY , Hammer GD , Schteingart DE , Maturen KE , Worden FP .

  Source

  Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.

  Abstract

  OBJECTIVE:

  To describe successful long-term tumor control in metastatic adrenocortical carcinoma, a relatively rare tumor with limited treatment options outside of surgery.

  METHODS:

  We present the clinical, radiologic, and pathologic findings in a patient with failure of or intolerance to conventional treatments for metastatic adrenocortical carcinoma.

  RESULTS:

  A 48-year-old man with adrenocortical carcinoma had disease progression with systemic therapies including mitotane, 5-fluorouracil, streptozotocin, bevacizumab, and external beam radiation therapy. Treatment with all chemotherapeutic drugs was ceased, and he was prescribed mebendazole , 100 mg twice daily, as a single agent. His metastases initially regressed and subsequently remained stable. While receiving mebendazole as a sole treatment for 19 months, his disease remained stable. He did not experience any clinically significant adverse effects, and his quality of life was satisfactory. His disease subsequently progressed after 24 months of mebendazole monotherapy.

  CONCLUSION:

  Mebendazole may achieve long-term disease control of metastatic adrenocortical carcinoma. It is well tolerated and the associated adverse effects are minor.
• 

  botchtowersociety

  http://www.ncbi.nlm.nih.gov/pubmed/18667591

  Mebendazole induces apoptosis via Bcl-2 inactivation in chemoresistant melanoma cells.

  Doudican N , Rodriguez A , Osman I , Orlow SJ .

  Source

  New York University School of Medicine, New York, NY 10016, USA.

  Abstract

  Most metastatic melanoma patients fail to respond to available therapy, underscoring the need for novel approaches to identify new effective treatments. In this study, we screened 2,000 compounds from the Spectrum Library at a concentration of 1 micromol/L using two chemoresistant melanoma cell lines (M-14 and SK-Mel-19) and a spontaneously immortalized, nontumorigenic melanocyte cell line (melan-a). We identified 10 compounds that inhibited the growth of the melanoma cells yet were largely nontoxic to melanocytes. Strikingly, 4 of the 10 compounds ( mebendazole , albendazole, fenbendazole, and oxybendazole) are benzimidazoles, a class of structurally related, tubulin-disrupting drugs. Mebendazole was prioritized to further characterize its mechanism of melanoma growth inhibition based on its favorable pharmacokinetic profile. Our data reveal that mebendazole inhibits melanoma growth with an average IC(50) of 0.32 micromol/L and preferentially induces apoptosis in melanoma cells compared with melanocytes. The intrinsic apoptotic response is mediated through phosphorylation of Bcl-2, which occurs rapidly after treatment with mebendazole in melanoma cells but not in melanocytes. Phosphorylation of Bcl-2 in melanoma cells prevents its interaction with proapoptotic Bax, thereby promoting apoptosis. We further show that mebendazole -resistant melanocytes can be sensitized through reduction of Bcl-2 protein levels, showing the essential role of Bcl-2 in the cellular response to mebendazole -mediated tubulin disruption. Our results suggest that this screening approach is useful for identifying agents that show promise in the treatment of even chemoresistant melanoma and identifies mebendazole as a potent, melanoma-specific cytotoxic agent.
• 

  botchtowersociety

  http://www.ncbi.nlm.nih.gov/pubmed/17581752

  Mebendazole inhibits growth of human adrenocortical carcinoma cell lines implanted in nude mice.

  Martarelli D , Pompei P , Baldi C , Mazzoni G .

  Source

  Department of Experimental Medicine and Public Health, University of Camerino, Via M. Scalzino 3, 62032 Camerino (Macerata), Italy. [email protected]

  Abstract

  Adrenocortical carcinoma is a rare tumor of the adrenal gland which requires new therapeutic approaches as its early diagnosis is difficult and prognosis poor despite therapies used. Recently, mebendazole has been proved to be effective against different cancers. The aim of our study was to evaluate whether mebendazole may result therapeutically useful in the treatment of human adrenocortical carcinoma. We analyzed the effect of mebendazole on human adrenocortical carcinoma cells in vitro and after implantation in nude mice. In order to clarify mechanisms of mebendazole action, metastases formation, apoptosis and angiogenesis were also investigated. Mebendazole significantly inhibited cancer cells growth, both in vitro and in vivo, the effects being due to the induction of apoptosis. Moreover, mebendazole inhibited invasion and migration of cancer cells in vitro, and metastases formation in vivo. Overall, these data suggest that treatment with mebendazole , also in combination with standard therapies, could provide a new protocol for the inhibition of adrenocortical carcinoma growth.
• 

  botchtowersociety

  This is how taxols work, they break up tubulins. Since new tubulins must be manufactured for mitosis, it inhibits cancer proliferation.

  http://www.ncbi.nlm.nih.gov/pubmed/12479701

  The anthelmintic drug mebendazole induces mitotic arrest and apoptosis by depolymerizing tubulin in non-small cell lung cancer cells.

  Sasaki J , Ramesh R , Chada S , Gomyo Y , Roth JA , Mukhopadhyay T .

  Source

  Section of Thoracic Molecular Oncology, Department of Thoracic and Cardiovascular Surgery, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.

  Abstract

  Microtubules have a critical role in cell division, and consequently various microtubule inhibitors have been developed as anticancer drugs. In this study, we assess mebendazole (MZ), a microtubule-disrupting anthelmintic that exhibits a potent antitumor property both in vitro and in vivo. Treatment of lung cancer cell lines with MZ caused mitotic arrest, followed by apoptotic cell death with the feature of caspase activation and cytochrome c release. MZ induces abnormal spindle formation in mitotic cancer cells and enhances the depolymerization of tubulin, but the efficacy of depolymerization by MZ is lower than that by nocodazole. Oral administration of MZ in mice elicited a strong antitumor effect in a s.c. model and reduced lung colonies in experimentally induced lung metastasis without any toxicity when compared with paclitaxel-treated mice. We speculate that tumor cells may be defective in one mitotic checkpoint function and sensitive to the spindle inhibitor MZ. Abnormal spindle formation may be the key factor determining whether a cell undergoes apoptosis, whereas strong microtubule inhibitors elicit toxicity even in normal cells.
• 

  Witness 007

  Interesting article. Yes news reports here in Australia are talking about common Asprin's effect on slowing tumors!!!!! And Baking soda...don't laugh, there is evidence it works and why. Vormox too. Layatrile {apricot seeds are banned in Australia even though no record of anyone being harmed by them.}

  Remember Chemo is SO TOXIC they keep it in glass jars because it MELTS the plastic ones. It was invented in the 1930's and IS STILL USED IN 2012 ........80 YEARS LATER and after Billions of $$$$$$ we still have NOTHING to show for it!
• 

  JeffT
• 

  JeffT

  As Talesin pointed out, personal experience colors our opinions. Here is my personal experience. My brother is a doctor, a few years ago he gave up private practice to work on a Native American reservation because they needed the help. My sister is a doctor - doing infectious disease research at UNM - those pharmaceutical companies you guys hate are paying for the work and providing drugs for people that can't afford them. My father spent most of his life trying, and largely suceeding, to cure leukemia.

  Frankly, many of the people on this thread don't know what the hell they're talking about.

  A few examples:

  If the mitosis is stopped, how does cancer grow?

  In a sense you are right, cancer won't grow, mainly because the patient will be dead.

  Remember Chemo is SO TOXIC they keep it in glass jars because it MELTS the plastic ones. It was invented in the 1930's and IS STILL USED IN 2012 ........80 YEARS LATER and after Billions of $$$$$$ we still have NOTHING to show for it!

  I have no idea where you came up with the glass bottles. I've seen chemotherapy agents (I used to work in my Dad's lab) packaged all kinds of ways. Lots of drugs are stored in glass because drugs are highly reactive chemicals (they wouldn't work if the weren't) and most things don't interact with glass. Saying that chemo was invented in the '30's and we still use it, is a bit like saying the airplane was invented in 1903 and we're still flying around in them. Actually we have a lot to show for chemotherapy and other treatements. When my Dad first started working on leukemia, a diagnosis was a death sentence, most patients died within a month or two. Last year the Fred Hutchinson center had a patient reunion, thanks to chemotherapy, radiation and bone marrow transplants there were attendees that are alive and kicking thirty or more years after their diagnosis.

  Laetrile: In the 1970's I worked for the College of Pharmacy at Washington State U. One of the professors was doing research on cyanotic compounds for the Department of Defense. We did some work on laetrile because of its cyanide content. {cyanide, there's a nice safe alternative to chemo http://en.wikipedia.org/wiki/Amygdalin ) One of the problems we quickly ran into was that no one knows what laetrile is. (see article). If you make laetrile from peach pits from Wenatchee and peach pits from Yakima you get two different compounds. As previously noted, both will contain cyanide.

  I hate to break this to you but there are no magic bullets out there that will feed us all, cure cancer or otherwise end human suffering. I believe firmly that the human race can and will advance in many areas of life, but it is going to take hard work, not tilting at windmills in the form of nonexistent conspiracies to cover up the solution to all our ills.
• 

  JeffT

  One more:

  there is a difference between published articles, and the medical profession lobbying for change

  For the scientific community lobbying starts with publication, in this case that process started with the 1951 article and came to public notice with the article in Reader's Digest. The 1965 cigarette warning labels were a direct result of lobbying from the activist portion of the medical community.
• 

  talesin

  JeffT - Still, you fail to acknowledge the studies/reports bought and paid for by the tobacco companies.

  I have had some excellent physicians in my life, and one in particular, whose empathy and true caring for his patients was a saving factor in my life. That does NOT mean that all physicians are ethical .... if you believe that there are not many who are in it FOR THE MONEY, then you are seeing this issue through rose-coloured glasses, as far as I'm concerned.

  And does the medical profession bear no responsibility for the epidemic of narcotic and anti-depressant addictions? wow, I wonder who is prescribing all these unnecessary drugs.

  Oh well, we will just have to disagree on this.

  t
• 

  Band on the Run

  I don't doubt that decisions regarding cancer research are very political and commercial. It is hard to know the larger picture from anectodal stories. My anecdotal story involves agonzing facial pain with a suicide rate greater than 95%. Dentists aren't used to telling people there is no treatment. My pain relief was to kill myself. B/c my life was so great before the onset, I refused to give up. I did my own research and found a small group of doctors (a handful in the US, some in Chrina) that were pioneering a new take on neuralgia. I happened to have one of the most severe cases. In the past, I mocked Steve McQueen for flying to Mexico for laterile. Well, when you wear the shoes and there is no hope, you grasp at straws.

  I tried all sorts of herbs and crazy stuff like drinking mineral oil as though it were a cure for everything. B/c dentists were not honest in their assessment, I had trouble making good decisions. I tried all sorts of Chinese herbs, acupuncture and qi chong. Nothing helped. The Chinese doctor in the herb shop told my it would not help. Finally, the oral surgeons made an analogy to nectoric hips after chemotherapy. A world famous innovative hematologist studied my blood for certain factors that are not normally test. Within a few weeks of taking a blood thinner, my pain went into remission for the first time in 25 years!

  I don't understand why so many people hated medicine and science. Unless the supplements and alternative therapies are harmful, they can exist with medicine. Using them bought me some hope. Sometimes hope itself is very precious. Even with the mineral oil, I was doing something. If I listened to medicine, though, I would not be alive. Friends always told me how great their doctors were. I felt I just could not find a good doctor. Well, when they became seriously ill, their view of their doctor changed.